PDIA3 Back

protein disulfide isomerase family A, member 3

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NCBI Description of PDIA3
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

Community Annotation of PDIA3 Add / Edit PDIA3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDIA3 is highly significantly mutated in
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PDIA3 is significantly mutated in
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PDIA3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PDIA3