PDE8B Back

phosphodiesterase 8B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PDE8B

The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PDE8B Add / Edit PDE8B: Annotations

No community annotations yet for PDE8B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PDE8B is highly significantly mutated in
PDE8B is significantly mutated in
PDE8B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PDE8B