PDE8A Back

phosphodiesterase 8A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PDE8A
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PDE8A Add / Edit PDE8A: Annotations

No community annotations yet for PDE8A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDE8A is highly significantly mutated in
(none)
PDE8A is significantly mutated in
(none)
PDE8A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PDE8A