PDE6G Back

phosphodiesterase 6G, cGMP-specific, rod, gamma

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NCBI Description of PDE6G
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDE6G is highly significantly mutated in
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PDE6G is significantly mutated in
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PDE6G is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PDE6G