PDCD2 Back

programmed cell death 2

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NCBI Description of PDCD2
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.

Community Annotation of PDCD2 Add / Edit PDCD2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDCD2 is highly significantly mutated in
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PDCD2 is significantly mutated in
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PDCD2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PDCD2