PDCD10 Back

programmed cell death 10

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PDCD10

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Community Annotation of PDCD10 Add / Edit PDCD10: Annotations

No community annotations yet for PDCD10.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PDCD10 is highly significantly mutated in
PDCD10 is significantly mutated in
PDCD10 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PDCD10