PCSK6 Back

proprotein convertase subtilisin/kexin type 6

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NCBI Description of PCSK6
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of PCSK6 Add / Edit PCSK6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCSK6 is highly significantly mutated in
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PCSK6 is significantly mutated in
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PCSK6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PCSK6