procollagen C-endopeptidase enhancer

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PCOLCE

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.

Community Annotation of PCOLCE Add / Edit PCOLCE: Annotations

No community annotations yet for PCOLCE.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PCOLCE is highly significantly mutated in
PCOLCE is significantly mutated in
PCOLCE is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PCOLCE