PCM1 Back

pericentriolar material 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PCM1

The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of PCM1 Add / Edit PCM1: Annotations

No community annotations yet for PCM1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCM1 is highly significantly mutated in
(none)
PCM1 is significantly mutated in
(none)
PCM1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PCM1