PCLO Back

piccolo (presynaptic cytomatrix protein)

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NCBI Description of PCLO

The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PCLO Add / Edit PCLO: Annotations

No community annotations yet for PCLO.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCLO is highly significantly mutated in
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PCLO is significantly mutated in
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PCLO is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PCLO