PCGF6 Back

polycomb group ring finger 6

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NCBI Description of PCGF6
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of PCGF6 Add / Edit PCGF6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCGF6 is highly significantly mutated in
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PCGF6 is significantly mutated in
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PCGF6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PCGF6