PCDHB6 Back

protocadherin beta 6

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PCDHB6

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Community Annotation of PCDHB6 Add / Edit PCDHB6: Annotations

No community annotations yet for PCDHB6.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCDHB6 is highly significantly mutated in
(none)
PCDHB6 is significantly mutated in
(none)
PCDHB6 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PCDHB6