PCDH11Y Back

protocadherin 11 Y-linked

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NCBI Description of PCDH11Y
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation.

Community Annotation of PCDH11Y Add / Edit PCDH11Y: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCDH11Y is highly significantly mutated in
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PCDH11Y is significantly mutated in
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PCDH11Y is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PCDH11Y