PCBP4 Back

poly(rC) binding protein 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PCBP4

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.

Community Annotation of PCBP4 Add / Edit PCBP4: Annotations

No community annotations yet for PCBP4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PCBP4 is highly significantly mutated in
(none)
PCBP4 is significantly mutated in
(none)
PCBP4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PCBP4