PBX2 Back

pre-B-cell leukemia homeobox 2

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NCBI Description of PBX2
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PBX2 is highly significantly mutated in
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PBX2 is significantly mutated in
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PBX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PBX2