PAWR Back

PRKC, apoptosis, WT1, regulator

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NCBI Description of PAWR

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.

Community Annotation of PAWR Add / Edit PAWR: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PAWR is highly significantly mutated in
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PAWR is significantly mutated in
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PAWR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PAWR