PAS domain containing serine/threonine kinase

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NCBI Description of PASK

This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PASK Add / Edit PASK: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PASK is highly significantly mutated in
PASK is significantly mutated in
PASK is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PASK