PARP3 Back

poly (ADP-ribose) polymerase family, member 3

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NCBI Description of PARP3
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of PARP3 Add / Edit PARP3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PARP3 is highly significantly mutated in
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PARP3 is significantly mutated in
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PARP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PARP3