presenilin associated, rhomboid-like

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PARL

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of PARL Add / Edit PARL: Annotations

No community annotations yet for PARL.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PARL is highly significantly mutated in
PARL is significantly mutated in
PARL is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PARL