poly (ADP-ribose) glycohydrolase

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NCBI Description of PARG

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PARG is highly significantly mutated in
PARG is significantly mutated in
PARG is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PARG