3'-phosphoadenosine 5'-phosphosulfate synthase 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PAPSS1

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008].

Community Annotation of PAPSS1 Add / Edit PAPSS1: Annotations

No community annotations yet for PAPSS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PAPSS1 is highly significantly mutated in
PAPSS1 is significantly mutated in
PAPSS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PAPSS1