pappalysin 2

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NCBI Description of PAPPA2

This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PAPPA2 is highly significantly mutated in
PAPPA2 is significantly mutated in
PAPPA2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PAPPA2