PAPPA2 Back

pappalysin 2

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NCBI Description of PAPPA2
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.

Community Annotation of PAPPA2 Add / Edit PAPPA2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PAPPA2 is highly significantly mutated in
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PAPPA2 is significantly mutated in
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PAPPA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PAPPA2