NCBI Description of PAPPA
|This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. Sequence Note: The sequence U28727.1 is a chimeric mRNA clone. Only the pregnancy-associated plasma protein A region was propagated into this RefSeq record.|
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