PAPPA Back

pregnancy-associated plasma protein A, pappalysin 1

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NCBI Description of PAPPA
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. Sequence Note: The sequence U28727.1 is a chimeric mRNA clone. Only the pregnancy-associated plasma protein A region was propagated into this RefSeq record.

Community Annotation of PAPPA Add / Edit PAPPA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PAPPA is highly significantly mutated in
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PAPPA is significantly mutated in
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PAPPA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PAPPA