PAK2 Back

p21 (CDKN1A)-activated kinase 2

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NCBI Description of PAK2

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Community Annotation of PAK2 Add / Edit PAK2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PAK2 is highly significantly mutated in
PAK2 is significantly mutated in
PAK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PAK2