PAIP2B Back

poly(A) binding protein interacting protein 2B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PAIP2B
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of PAIP2B Add / Edit PAIP2B: Annotations

No community annotations yet for PAIP2B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PAIP2B is highly significantly mutated in
(none)
PAIP2B is significantly mutated in
(none)
PAIP2B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PAIP2B