PAF1 Back

Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

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NCBI Description of PAF1
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PAF1 Add / Edit PAF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PAF1 is highly significantly mutated in
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PAF1 is significantly mutated in
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PAF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PAF1