PACS1 Back

phosphofurin acidic cluster sorting protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PACS1
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

Community Annotation of PACS1 Add / Edit PACS1: Annotations

No community annotations yet for PACS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PACS1 is highly significantly mutated in
(none)
PACS1 is significantly mutated in
(none)
PACS1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PACS1