P4HTM Back

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

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NCBI Description of P4HTM

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

Community Annotation of P4HTM Add / Edit P4HTM: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


P4HTM is highly significantly mutated in
P4HTM is significantly mutated in
P4HTM is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for P4HTM