P2RY12 Back

purinergic receptor P2Y, G-protein coupled, 12

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NCBI Description of P2RY12

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


P2RY12 is highly significantly mutated in
P2RY12 is significantly mutated in
P2RY12 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for P2RY12