P2RX4 Back

purinergic receptor P2X, ligand-gated ion channel, 4

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NCBI Description of P2RX4

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


P2RX4 is highly significantly mutated in
P2RX4 is significantly mutated in
P2RX4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for P2RX4