P2RX3 Back

purinergic receptor P2X, ligand-gated ion channel, 3

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NCBI Description of P2RX3

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


P2RX3 is highly significantly mutated in
P2RX3 is significantly mutated in
P2RX3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for P2RX3