OXCT1 Back

3-oxoacid CoA transferase 1

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NCBI Description of OXCT1

This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OXCT1 is highly significantly mutated in
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OXCT1 is significantly mutated in
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OXCT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for OXCT1