OTX1 Back

orthodenticle homeobox 1

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NCBI Description of OTX1

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternate splicing results in two transcript variants that encoded the same protein.

Community Annotation of OTX1 Add / Edit OTX1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


OTX1 is highly significantly mutated in
OTX1 is significantly mutated in
OTX1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for OTX1