OTUB2 Back

OTU domain, ubiquitin aldehyde binding 2

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NCBI Description of OTUB2
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of OTUB2 Add / Edit OTUB2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OTUB2 is highly significantly mutated in
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OTUB2 is significantly mutated in
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OTUB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OTUB2