OTUB1 Back

OTU domain, ubiquitin aldehyde binding 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of OTUB1

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Community Annotation of OTUB1 Add / Edit OTUB1: Annotations

No community annotations yet for OTUB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


OTUB1 is highly significantly mutated in
OTUB1 is significantly mutated in
OTUB1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for OTUB1