OSCAR Back

osteoclast associated, immunoglobulin-like receptor

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of OSCAR
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of OSCAR Add / Edit OSCAR: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OSCAR is highly significantly mutated in
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OSCAR is significantly mutated in
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OSCAR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OSCAR