OSBPL2 Back

oxysterol binding protein-like 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of OSBPL2

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.

Community Annotation of OSBPL2 Add / Edit OSBPL2: Annotations

No community annotations yet for OSBPL2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OSBPL2 is highly significantly mutated in
(none)
OSBPL2 is significantly mutated in
(none)
OSBPL2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for OSBPL2