OS9 Back

osteosarcoma amplified 9, endoplasmic reticulum lectin

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NCBI Description of OS9
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of OS9 Add / Edit OS9: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OS9 is highly significantly mutated in
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OS9 is significantly mutated in
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OS9 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OS9