ORAI1 Back

ORAI calcium release-activated calcium modulator 1

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NCBI Description of ORAI1
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

Community Annotation of ORAI1 Add / Edit ORAI1: Annotations

No community annotations yet for ORAI1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ORAI1 is highly significantly mutated in
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ORAI1 is significantly mutated in
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ORAI1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ORAI1