OPTC Back

opticin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of OPTC
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).

Community Annotation of OPTC Add / Edit OPTC: Annotations

No community annotations yet for OPTC.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OPTC is highly significantly mutated in
(none)
OPTC is significantly mutated in
(none)
OPTC is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OPTC