5-oxoprolinase (ATP-hydrolysing)

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NCBI Description of OPLAH

The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD).

Community Annotation of OPLAH Add / Edit OPLAH: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


OPLAH is highly significantly mutated in
OPLAH is significantly mutated in
OPLAH is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for OPLAH