ONECUT2 Back

one cut homeobox 2

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NCBI Description of ONECUT2
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon, which is conserved in other vertebrates, including mouse, opossum, pig and zebrafish. An alternative downstream start codon, which has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 19 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo.

Community Annotation of ONECUT2 Add / Edit ONECUT2: Annotations

No community annotations yet for ONECUT2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ONECUT2 is highly significantly mutated in
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ONECUT2 is significantly mutated in
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ONECUT2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ONECUT2