ONECUT1 Back

one cut homeobox 1

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NCBI Description of ONECUT1
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ONECUT1 is highly significantly mutated in
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ONECUT1 is significantly mutated in
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ONECUT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ONECUT1