OLIG2 Back

oligodendrocyte lineage transcription factor 2

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NCBI Description of OLIG2

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Community Annotation of OLIG2 Add / Edit OLIG2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OLIG2 is highly significantly mutated in
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OLIG2 is significantly mutated in
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OLIG2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for OLIG2