OGDH Back

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of OGDH
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of OGDH Add / Edit OGDH: Annotations

No community annotations yet for OGDH.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OGDH is highly significantly mutated in
(none)
OGDH is significantly mutated in
(none)
OGDH is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OGDH