OAS1 Back

2',5'-oligoadenylate synthetase 1, 40/46kDa

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NCBI Description of OAS1
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of OAS1 Add / Edit OAS1: Annotations

No community annotations yet for OAS1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

OAS1 is highly significantly mutated in
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OAS1 is significantly mutated in
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OAS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for OAS1