NUMB Back

numb homolog (Drosophila)

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NCBI Description of NUMB
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NUMB Add / Edit NUMB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NUMB is highly significantly mutated in
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NUMB is significantly mutated in
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NUMB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NUMB