NUF2 Back

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

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NCBI Description of NUF2
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NUF2 is highly significantly mutated in
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NUF2 is significantly mutated in
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NUF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NUF2