NUDT4 Back

nudix (nucleoside diphosphate linked moiety X)-type motif 4

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NCBI Description of NUDT4
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.

Community Annotation of NUDT4 Add / Edit NUDT4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NUDT4 is highly significantly mutated in
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NUDT4 is significantly mutated in
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NUDT4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NUDT4