NUDT3 Back

nudix (nucleoside diphosphate linked moiety X)-type motif 3

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NCBI Description of NUDT3
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of NUDT3 Add / Edit NUDT3: Annotations

No community annotations yet for NUDT3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NUDT3 is highly significantly mutated in
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NUDT3 is significantly mutated in
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NUDT3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NUDT3